Blocking PD-L2 clears ageing cells in mice
By the AFREEQUE newsroom, based on Weekendpost
Researchers have identified the protein PD-L2 as a mechanism that allows senescent cells to evade immune defences in mice. Blocking the protein helped eliminate them and improved some metabolic and physical markers, suggesting a possible avenue for age-related disorders, Weekendpost reports.
Blocking the immune protein PD-L2 enabled mice to eliminate more senescent cells, damaged, ageing cells that persist in tissues. The experiments also showed improvements in their metabolic health and physical performance, according to research findings reported by Weekendpost.
Senescent cells, sometimes nicknamed “zombie cells”, can evade immune defences with the help of PD-L2. These observations suggest that restoring immune surveillance could help treat certain age-related disorders, although the reported results concern experiments in mice.
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Summary produced with the help of artificial intelligence tools, under AFREEQUE’s editorial responsibility.
